Compound 150441

Chemical Structure : Compound 150441

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货号: PC-24302Not For Human Use, Lab Use Only.

Compound 150441 is a highly specific small molecule inhibitor of Cdc2-like kinase 4 (CLK4) with IC50 of 21.4 nM.

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生物&药学活性

Compound 150441 is a highly specific small molecule inhibitor of Cdc2-like kinase 4 (CLK4) with IC50 of 21.4 nM.
Compound 150441exhibits weaker inhibitory activity against CLK1, CLK2, and CLK3, as well as against a panel of 60 kinases.
Compound 150441 (10 uM) exhibits significant cytotoxicity (IC50<1 uM) and more than 95% anti-proliferative effects in both Mia PaCa-2 and Panc-1 cell lines.
Compound 150441 affects SR protein activity and subsequently influence the RNA splicing process.
Compound 150441 at 3 and 10 uM led to a substantial downregulation of the anti-apoptotic proteins Mcl-1 and Bcl-2, along with the activation of the caspase-dependent apoptotic pathway in Mia PaCa-2 and Panc-1 cell lines.

物理化学性质&存储条件

分子量	317.44
分子式	C21H23N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5,11-dimethyl-6H-pyrido[4,3-b]carbazol-6-yl)-N,N-dimethylethan-1-amine

参考文献

1. Yang CL, et al. Adv Sci (Weinh). 2025 Mar 24:e2416323.

Compound 150441

生物&药学活性

物理化学性质&存储条件

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Compound 150441

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物理化学性质&存储条件

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