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首页-小分子抑制剂&激动剂-Others-Glycosyltransferase-Compound 1105486
Compound 1105486

Chemical Structure : Compound 1105486

CAS No.: 683794-45-8

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Compound 1105486

货号: PC-25464Not For Human Use, Lab Use Only.

Compound 1105486 is a selective small molecule inhibitor of β-1,4-galactosyltransferase 1 (B4GALT1), suppresses PANC-1 cell proliferation with an IC50 of 19.8 uM, exhibiting no significant cytotoxicity toward hTERT-HPNE normal pancreatic ductal epithelial cells up to 80 uM

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Compound 1105486 is a selective small molecule inhibitor of β-1,4-galactosyltransferase 1 (B4GALT1), suppresses PANC-1 cell proliferation with an IC50 of 19.8 uM, exhibiting no significant cytotoxicity toward hTERT-HPNE normal pancreatic ductal epithelial cells up to 80 uM.

物理化学性质&存储条件

分子量 471.50
分子式 C23H22FN3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3-cyano-6-oxo-4-(3,4,5-trimethoxyphenyl)-3,4,5,6-tetrahydropyridin-2-yl)thio)-N-(4-fluorophenyl)acetamide

参考文献

1. Yunyun X, et al. Front Chem. 2025 Aug 11;13:1651402.

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