欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Colivelin
Colivelin

Chemical Structure : Colivelin

CAS No.: 867021-83-8

加入收藏

Colivelin

货号: PC-25391Not For Human Use, Lab Use Only.

Colivelin is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro.

规格 价格 库存 数量
1 mg ￥1580 In stock
2 mg ￥2480 In stock
5 mg ￥4280 In stock
10 mg Get quote
50 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Colivelin is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro.
Colivelin is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17.
Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Abeta1-43 at a concentration of 100 fM.
Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by STAT3, triggered by humanin (HN).
Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Abeta25-35 or Abeta1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Abeta1-42.

物理化学性质&存储条件

分子量 2645.15
分子式 C119H206N32O35
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-

参考文献

1. Chiba T, et al. J Neurosci. 2005 Nov 2;25(44):10252-61.

2. Chiba T, et al. Biochem Biophys Res Commun. 2006 May 12;343(3):793-8.

3. Chiba T, et al. Mol Neurobiol. 2007 Feb;35(1):55-84.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: