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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-Clonixeril
Clonixeril

Chemical Structure : Clonixeril

CAS No.: 21829-22-1

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Clonixeril (NSC 335504, CXL)

货号: PC-24871Not For Human Use, Lab Use Only.

Clonixeril (CXL) is a highly potent, non-nucleotide hSTING modulator, has two modes of interaction with hSTING, shows weak agonist activity at micromolar concentrations, acts as a hSTING antagonist at <1 nM (EC50 < 1fM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Clonixeril (CXL) is a highly potent, non-nucleotide hSTING modulator, has two modes of interaction with hSTING, shows weak agonist activity at micromolar concentrations, acts as a hSTING antagonist at <1 nM (EC50 < 1fM).
Clonixeril displays this exceptionally strong inhibitory effect on hSTING mediated IFN-1 production using a THP-1 cell luciferase reporter for interferon regulatory factor 3 (IRF3).
Clonixeril is a potent inhibitor of hSTING, with activity even at attomolar (10-18 M) concentrations
Clonixeril reduces hSTING oligomerization at concentrations down to attomolar levels with an inverse dose response.
Clonixeril binds to hSTING CTD with SPR KD of 430 nM.

物理化学性质&存储条件

分子量 336.77
分子式 C16H17ClN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyridinecarboxylic acid, 2-[(3-chloro-2-methylphenyl)amino]-, 2,3-dihydroxypropyl ester

参考文献

1. Sparks RP, et al. ACS Cent Sci. 2025 Jun 6;11(6):994-1008.

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