Clocinizine

Chemical Structure : Clocinizine

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货号: PC-25438Not For Human Use, Lab Use Only.

Clocinizine is a chlorinated analogue of cinnarizine, shows potent antischistosomal activity against both male and female parasites with EC50 and EC90 of 4.6 uM and 5.9 uM respectively.

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生物&药学活性

Clocinizine is a chlorinated analogue of cinnarizine, shows potent antischistosomal activity against both male and female parasites with EC50 and EC90 of 4.6 uM and 5.9 uM respectively.
Clocinizine demonstrated a clear time- and concentration-dependent effect on both male and female worms.
Clocinizine (400 mg/kg) significantly reduced the total worm burden by 86.4% (P < 0.001) in animal model infected with S. mansoni.

物理化学性质&存储条件

分子量	402.97
分子式	C26H27ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((4-chlorophenyl)(phenyl)methyl)-4-cinnamylpiperazine

参考文献

1. Castro T, et al. Sci Rep. 2025 Aug 21;15(1):30816.

Clocinizine

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Clocinizine

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