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首页-抗体和重组蛋白-Biosimilar Antibody-Clazakizumab
Clazakizumab

Chemical Structure : Clazakizumab

CAS No.: 1236278-28-6

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Clazakizumab (Anti-human IL-6 mAb, human IgG1-Kappa; BMS 945429; ALD518)

货号: PC-Ab1084Not For Human Use, Lab Use Only.

Clazakizumab (ALD518, BMS 945429) a humanized anti–IL-6 mAb, targets human IL-6 with an affinity of 4 pM, binds circulating IL-6 cytokine rather than the IL-6 receptor 10, 11, blocking both classic signaling and trans-signaling. significantly improves disease activity in rheumatoid arthritis (RA). It has also been evaluated for the treatment of non-small cell lung cancer (NSCLC) and patients with head and neck cancer..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Clazakizumab (ALD518, BMS 945429) a humanized anti–IL-6 mAb, targets human IL-6 with an affinity of 4 pM, binds circulating IL-6 cytokine rather than the IL-6 receptor 10, 11, blocking both classic signaling and trans-signaling. significantly improves disease activity in rheumatoid arthritis (RA). It has also been evaluated for the treatment of non-small cell lung cancer (NSCLC) and patients with head and neck cancer.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Clazakizumab; ALD518; BMS 945429;1236278-28-6; Anti-human IL-6; anti-human Interleukin 6

参考文献

1. 1, Bayliss TJ, et al. Expert Opin Biol Ther. 2011 Dec;11(12):1663-8. 2, Karkhur S, et al. J Ophthalmic Inflamm Infect. 2019 Sep 16;9(1):17. 3, Weinblatt ME, et al. Arthritis Rheumatol. 2015 Oct;67(10):2591-600. 4, Mühlbacher J, et al. Transpl Int. 2021 Aug;34(8):1542-1552.

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