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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-Cl-amidine hydrochloride
Cl-amidine hydrochloride

Chemical Structure : Cl-amidine hydrochloride

CAS No.: 1373232-26-8

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Cl-amidine hydrochloride (pan-PAD inhibitor)

货号: PC-22865Not For Human Use, Lab Use Only.

Cl-amidine hydrochloride is a potent, irreversible, orall active inhibitor of protein arginine deiminases (PADs) with IC50 of 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cl-amidine hydrochloride is a potent, irreversible, orall active inhibitor of protein arginine deiminases (PADs) with IC50 of 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively.
Cl-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively).
Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil extracellular trap (NET) formation and increases survival in a mouse model of sepsis induced by cecal ligation and puncture (CLP).
Cl-amidine also decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis in a dose-dependent manner.

物理化学性质&存储条件

分子量 347.24
分子式 C14H19ClN4O2 • HCl
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(1-amino-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)benzamide hydrochloride

参考文献

1. Yuan Luo, et al. Biochemistry. 2006 Oct 3; 45(39): 11727–11736.

2. Witalison EE, et al. Oncotarget. 2015 Nov 3;6(34):36053-62.

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