Chemical Structure : ChREBPα-14-3-3 PPI stabilizer 43
CAS No.:
3067202-14-3
ChREBPα-14-3-3 PPI stabilizer 43
货号: PC-24500Not For Human Use, Lab Use Only.
ChREBPα/14-3-3 PPI stabilizer 43 is a potent, specific molecular glue as ChREBPα/14-3-3 protein-protein interaction (PPI) stabilizer with EC50 of 3.8 uM, protect human β-cells from glucolipotoxicity.
大包装，大折扣！
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
ChREBPα/14-3-3 PPI stabilizer 43 is a potent, specific molecular glue as ChREBPα/14-3-3 protein-protein interaction (PPI) stabilizer with EC50 of 3.8 uM, protect human β-cells from glucolipotoxicity.
ChREBPα/14-3-3 PPI stabilizer 43 displays a high selectivity for stabilizing ChREBPα, without affecting any other client peptide up to 100 µM (BRAF, CRAF, p65, USP8, one C-terminal binding motif ERα).
ChREBPα/14-3-3 PPI stabilizer 43 (5 uM, 10 uM) rescues human β-cells from glucolipotoxic death.
ChREBPα/14-3-3 PPI stabilizer 43 stabilizes the ChREBPα/14-3-3 interaction in situ preventing ChREBPα's nuclear translocation in response to glucose or glucose + palmitate, retains ChREBPα in the cytoplasm, preventing its transcriptional activity.
ChREBPα/14-3-3 PPI stabilizer 43 preserves β-cell identity in glucolipotoxicity and prevents upregulation of ChREBPβ in high glucose and glucolipotoxicity.
物理化学性质&存储条件
|
分子量
|
389.27
|
|
分子式
|
C16H15F3NO5P
|
|
外观性状
|
Solid
|
|
CAS No.
|
|
|
储存条件
|
- 固体粉末
-
-20°C 12 个月; 4°C 6 个月
|
- 配置液
-
-80°C 6 个月; -20°C 6 个月
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(2-(2-((2,2-difluoro-2-(3-fluorophenyl)ethyl)amino)-2-oxoethoxy)phenyl)phosphonic acid
|
参考文献
1. Katz LS, et al. Nat Commun. 2025 Mar 2;16(1):2110.
