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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P-glycoprotein (P-gp)-Ceefourin-2
Ceefourin-2

Chemical Structure : Ceefourin-2

CAS No.: 348148-51-6

Ceefourin-2 (Ceefourin 2)

货号: PC-26198Not For Human Use, Lab Use Only.

Ceefourin-2 (Ceefourin 2) is a highly selective inhibitor of multidrug resistance protein 4 (MRP4, ABCC4), inhibits transport of a broad range of MRP4 substrates, shows high selectivity over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Ceefourin-2 (Ceefourin 2) is a highly selective inhibitor of multidrug resistance protein 4 (MRP4, ABCC4), inhibits transport of a broad range of MRP4 substrates, shows high selectivity over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1.

物理化学性质&存储条件

分子量 355.70
分子式 C15H9ClF3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Chloro-5-(p-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

参考文献

1. Cheung L, et al. Biochem Pharmacol. 2014 Sep 1;91(1):97-108.

2. Zhu J, et al. Nat Commun. 2025 Dec 3. doi: 10.1038/s41467-025-66877-4.

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