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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-Cediranib maleate
Cediranib maleate

Chemical Structure : Cediranib maleate

CAS No.: 857036-77-2

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Cediranib maleate (AZD-2171 maleate, AZD2171 maleate)

货号: PC-43353Not For Human Use, Lab Use Only.

Cediranib maleate (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cediranib maleate (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.
Cediranib also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR.
Cediranib inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells.
Cediranib inhibits angiogenesis, neovascular survival and tumor growth in vivo.

物理化学性质&存储条件

分子量 566.5775
分子式 C29H31FN4O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 45 mg/mL
Chemical Name/SMILES

Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-, (2Z)-2-butenedioate (1:1)

参考文献

1. Wedge SR, et al. Cancer Res. 2005 May 15;65(10):4389-400.

2. Denduluri N, et al. Clin Breast Cancer. 2005 Dec;6(5):460-3.

3. Batchelor TT, et al. Cancer Cell. 2007 Jan;11(1):83-95.

4. Cao C, et al. Cancer Res. 2006 Dec 1;66(23):11409-15.

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