Cbl-b inhibitor 10

Chemical Structure : Cbl-b inhibitor 10

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货号: PC-25777Not For Human Use, Lab Use Only.

Cbl-b inhibitor 10 is a potent and orally bioavailable Casitas B-lineage lymphoma-b (CBLB, Cbl-b) inhibitor with biochemical IC50 of 9.1 nM, and EC50 of 180.6 nM in IL-2 secretion assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Cbl-b inhibitor 10 is a potent and orally bioavailable Casitas B-lineage lymphoma-b (CBLB, Cbl-b) inhibitor with biochemical IC50 of 9.1 nM, and EC50 of 180.6 nM in IL-2 secretion assays.
Cbl-b inhibitor 10 (3 mpk, 10 mpk, and 30 mpk) exhibits significant antitumor efficacy in CT26 mouse model.
Cbl-b inhibitor 10 synergizes strongly with anti-PD-1 therapy to enhance tumor regression, and induces durable immune memory against tumor rechallenge.

物理化学性质&存储条件

分子量	551.62
分子式	C29H32F3N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-((1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl)pyridin-2-yl)-6-(((S)-3-methylpiperidin-1-yl)methyl)-8-(trifluoromethyl)quinazolin-4(3H)-one

参考文献

1. Meng F, et al. J Med Chem. 2025 Nov 12. doi: 10.1021/acs.jmedchem.5c02541.