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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Carvacrol
Carvacrol

Chemical Structure : Carvacrol

CAS No.: 499-75-2

Carvacrol (Cymophenol)

货号: PC-28517Not For Human Use, Lab Use Only.

Carvacrol (Cymophenol) is a small molecule agonist / activator of TRPV3 with EC50 of 0.39 uM, also is an inhibitor of Drosophila TRPL and mammalian TRPM7 channels, also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1 and induces apoptosis, shows antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Carvacrol (Cymophenol) is a small molecule agonist / activator of TRPV3 with EC50 of 0.39 uM, also is an inhibitor of Drosophila TRPL and mammalian TRPM7 channels, also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1 and induces apoptosis, shows antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties.

物理化学性质&存储条件

分子量 150.22
分子式 C10H14O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Isopropyl-2-methylphenol

参考文献

1. Xu H, et al. Nat Neurosci. 2006 May;9(5):628-35.

2. Vogt-Eisele AK, et al. Br J Pharmacol. 2007 Jun;151(4):530-40.

3. Parnas M, et al. Cell Calcium. 2009 Mar;45(3):300-9.

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