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首页-抗体和重组蛋白-Biosimilar Antibody-Caplacizumab
Caplacizumab

Chemical Structure : Caplacizumab

CAS No.: 915810-67-2

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Caplacizumab (Anti-human vWF mAb, human Fc; ALX-0081)

货号: PC-Ab1068Not For Human Use, Lab Use Only.

Caplacizumab (ALX0081) is a humanized single variable domain immunoglobulin (nanobody) against the von Willebrand factor (VWF). by targetting the A1 domain of the ultra-large von Willebrand factor which in order inhibits the interaction with the glycoprotein Ib-IX-V receptor in the platelets. Caplacizumab has used to treat acquired thrombotic thrombocytopenic purpura (aTTP)..

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5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Caplacizumab (ALX0081) is a humanized single variable domain immunoglobulin (nanobody) against the von Willebrand factor (VWF). by targetting the A1 domain of the ultra-large von Willebrand factor which in order inhibits the interaction with the glycoprotein Ib-IX-V receptor in the platelets. Caplacizumab has used to treat acquired thrombotic thrombocytopenic purpura (aTTP).

物理化学性质&存储条件

分子量
分子式 Human Fc
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Caplacizumab; Cablivi; Caplacizumab-yhdp; ALX-0081; ALX0081; 915810-67-2; anti human von Willebrand factor; anti human vWF; human vWF nanobody

参考文献

1. 1, Bartunek J, et al. J Cardiovasc Transl Res. 2013 Jun;6(3):355-63. 2, Muller O, et al. J Cardiovasc Transl Res. 2013 Jun;6(3):364-70. 3, Peyvandi F, et al. N Engl J Med. 2016 Feb 11;374(6):511-22. 4, Scully M, et al. N Engl J Med. 2019 Jan 24;380(4):335-346.

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