Calhex-231 (Calhex231)

Chemical Structure : Calhex-231

CAS No.: 652973-93-8

加入收藏

货号: PC-62905Not For Human Use, Lab Use Only.

Calhex-231 (Calhex231) is a potent negative allosteric modulator / antagonist of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Calhex-231 (Calhex231) is a potent negative allosteric modulator / antagonist of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.
Calhex-231 inhibits myocyte hyperpolarization to the CaSR activator calindol and R-568.

物理化学性质&存储条件

分子量	406.954
分子式	C25H27ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide

参考文献

1. Petrel C, et al. J Biol Chem. 2003 Dec 5;278(49):49487-94.

2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.

3. Kessler A, et al. J Med Chem. 2006 Aug 24;49(17):5119-28.