Cagrilintide | AMYR/CTR agonist | Probechem Biochemicals

Chemical Structure : Cagrilintide

CAS No.: 1415456-99-3

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Cagrilintide (AM833)

货号: PC-24754Not For Human Use, Lab Use Only.

规格	价格	库存
2 mg	￥1580	In stock
5 mg	￥2780	In stock
10 mg	￥4980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Cagrilintide (AM833) is a long-acting amylin analogue as a nonselective amylin receptor (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist with binding IC50 of 170 and 223 pM, and cAMP EC50 of 348 and 287 pM for hAMY3R and hCTR respectively.
Cagrilintide has demonstrated interesting clinical performance on body weight and is intended to assist in treatment of obesity-probably in combination with semaglutide.

物理化学性质&存储条件

分子量	4409.01
分子式	C194H312N54O59S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	l-prolinamide, n-(19-carboxy-1-oxononadecyl)-l-.gamma.-glutamyl-l-lysyl-l-cysteinyl-l-asparaginyl-l-threonyl-l-alanyl-l-threonyl-l-cysteinyl-l-alanyl-l-threonyl-l-glutaminyl-l-arginyl-l-leucyl-l-alanyl-l-.alpha.-glutamyl-l-phenylalanyl-l-leucyl-l-arginyl-l-histidyl-l-seryl-l-seryl-l-asparaginyl-l-asparaginyl-l-phenylalanylglycyl-l-prolyl-l-isoleucyl-l-leucyl-l-prolyl-l-prolyl-l-threonyl-l-asparaginyl-l-valylglycyl-l-seryl-l-asparaginyl-l-threonyl-, cyclic (3->8)-disulfide

参考文献

1. Kruse T, et al. J Med Chem. 2021 Aug 12;64(15):11183-11194.

2. Fletcher MM,, et al. J Pharmacol Exp Ther. 2021 Jun;377(3):417-440.

Cagrilintide (AM833)

生物&药学活性

物理化学性质&存储条件

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Cagrilintide (AM833)

生物&药学活性

物理化学性质&存储条件

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