Cabazitaxel (XRP6258) | Microtubule inhibitor | Probechem Biochemicals

Chemical Structure : Cabazitaxel

CAS No.: 183133-96-2

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Cabazitaxel (XRP6258, XRP 6258)

货号: PC-61247Not For Human Use, Lab Use Only.

Cabazitaxel (XRP6258) is a semi-synthetic taxane and microtubule inhibitor for the treatment of hormone-refractory prostate cancer.

规格	价格	库存
50 mg	￥780	In stock
100 mg	￥1180	In stock
500 mg	￥3480	In stock
1 g		Get quote

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生物&药学活性

Cabazitaxel (XRP6258) is a semi-synthetic taxane and microtubule inhibitor for the treatment of hormone-refractory prostate cancer.
Cabazitaxel possesses a favorable pharmacokinetic and safety profile, and a decreased propensity for P-glycoprotein (Pgp)-mediated drug resistance.

物理化学性质&存储条件

分子量	835.93
分子式	C45H57NO14
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

参考文献

1. Villanueva C, et al. Drugs. 2011 Jul 9;71(10):1251-8.

2. Madan RA, et al. Clin Cancer Res. 2011 Jun 15;17(12):3892-902.

3. Bouchet BP, et al. Drugs Today (Barc). 2010 Oct;46(10):735-42.

Cabazitaxel (XRP6258, XRP 6258)

生物&药学活性

物理化学性质&存储条件

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Cabazitaxel (XRP6258, XRP 6258)

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