CZL-149 | BET and p300/CBP inhibitor | Probechem Biochemicals

Chemical Structure : CZL-149

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CZL-149 (CZL149)

货号: PC-26789Not For Human Use, Lab Use Only.

CZL-149 is a highly potent, orally bioavailable dual inhibitor targeting BET and p300/CBP bromodomains with IC50 of 10.5 nM and 13 nM for p300 and BRD4 BD1 respectively.

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生物&药学活性

CZL-149 is a highly potent, orally bioavailable dual inhibitor targeting BET and p300/CBP bromodomains with IC50 of 10.5 nM and 13 nM for p300 and BRD4 BD1 respectively.
CZL-149 inhibits multiple myeloma OPM-2 cells with IC50 of 3.3 nM.
CZL-149 demonstrated antitumor efficacy (TGI=78%) and safety in vivo, outperformed NEO2734.

物理化学性质&存储条件

分子量	460.46
分子式	C23H23F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-4-(2-(tetrahydro-2H-pyran-4-yl)-1-(2-(trifluoromethoxy)ethyl)-1H-benzo[d]imidazol-6-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

参考文献

1. Chen Z, et al. J Med Chem. 2026 May 18. doi: 10.1021/acs.jmedchem.6c00468.

CZL-149 (CZL149)

生物&药学活性

物理化学性质&存储条件

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CZL-149 (CZL149)

生物&药学活性

物理化学性质&存储条件

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