CYP1B1 inhibitor B20

Chemical Structure : CYP1B1 inhibitor B20

加入收藏

货号: PC-25318Not For Human Use, Lab Use Only.

CYP1B1 inhibitor B20 is a potent, highly selective CYP1B1 inhibitor with IC50 of 1.48 nM, does not inhibit CYP1A1 and CYP1A2 (IC50>80 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CYP1B1 inhibitor B20 is a potent, highly selective CYP1B1 inhibitor with IC50 of 1.48 nM, does not inhibit CYP1A1 and CYP1A2 (IC50>80 uM).
B20 has negligible effects on other CYP isoforms (IC50 > 10 μM).
B20 exerts its effect by competing with substrates for binding to the CYP1B1 active site.
B20 enhances the sensitivity of A549/T cells to Taxol.
B20 significantly inhibits the migration and invasion of A549/T cells.

物理化学性质&存储条件

分子量	383.67
分子式	C16H9Cl3N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-Chlorophenyl)-N-(3,5-dichlorophenyl)thiazole-2-carboxamide

参考文献

1. Wang T, et al. J Med Chem. 2025 Jun 26;68(12):13089-13112.