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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-CYP1A1 inhibitor 47
CYP1A1 inhibitor 47

Chemical Structure : CYP1A1 inhibitor 47

CAS No.: 3065926-17-9

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CYP1A1 inhibitor 47

货号: PC-25294Not For Human Use, Lab Use Only.

CYP1A1 inhibitor 47 is a small molecule cytochrome P4501A1 (CYP1A1) inhibitor with IC50 of 0.2 uM and 0.01 uM in Caco-2 and CYhiRAW cells respectively, promotes macrophage phagocytosis, enhances macrophage-mediated bacterial clearance in vivo by inhibiting CYP1A1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CYP1A1 inhibitor 47 is a small molecule cytochrome P4501A1 (CYP1A1) inhibitor with IC50 of 0.2 uM and 0.01 uM in Caco-2 and CYhiRAW cells respectively, promotes macrophage phagocytosis, enhances macrophage-mediated bacterial clearance in vivo by inhibiting CYP1A1.

物理化学性质&存储条件

分子量 316.36
分子式 C20H16N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-5-(3-(2-Ethynylphenyl)acryloyl)-1,3-dimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

参考文献

1. Wang F, et al. J Med Chem. 2025 Jun 12;68(11):11606-11627.

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