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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-CYC-116
CYC-116

Chemical Structure : CYC-116

CAS No.: 693228-63-6

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CYC-116 (CYC 116, CYC116)

货号: PC-42650Not For Human Use, Lab Use Only.

CYC-116 (CYC116) is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM.

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10 mg ￥580 In stock
25 mg ￥880 In stock
50 mg ￥1380 In stock
100 mg ￥2280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CYC-116 (CYC116) is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM.
CYC-116 shows >50-fold selectivity over CDK1/2/4/7/9.
CYC-116 exhibits antiproliferative activity against a broad panel of cancer cell lines with IC50<1 uM.
CYC-116 is orally bioavailable and possesses anticancer activity in mice.

物理化学性质&存储条件

分子量 368.456
分子式 C18H20N6OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-

参考文献

1. Wang S, et al. J Med Chem. 2010 Jun 10;53(11):4367-78.

2. Zhou YH, et al. Chin J Integr Med. 2015 Aug;21(8):635-9.

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