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首页-抗体药物偶连体和PROTACs-PROTAC-CXJ2080
CXJ2080

Chemical Structure : CXJ2080

CAS No.:

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CXJ2080 (CXJ-2080)

货号: PC-26461Not For Human Use, Lab Use Only.

CXJ2080 is a potent, selective CDK7 PROTAC degrader with DC50 of 0.88 nM and Dmax >98% in MV4-11 cells, disrupts the CDK7-cyclin H-MAT1 complex, simultaneously suppressing MYC-driven oncogenic signaling while activating the p53-p21 tumor suppressor axis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CXJ2080 is a potent, selective CDK7 PROTAC degrader with DC50 of 0.88 nM and Dmax >98% in MV4-11 cells, disrupts the CDK7-cyclin H-MAT1 complex, simultaneously suppressing MYC-driven oncogenic signaling while activating the p53-p21 tumor suppressor axis.

物理化学性质&存储条件

分子量 1030.75
分子式 C51H68ClN11O6S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4R)-1-(2-(4-(7-(((1r,4r)-4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)cyclohexyl)amino)-7-oxoheptyl)-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Tu Y, et al. Leukemia. 2026 Mar 25. doi: 10.1038/s41375-026-02925-2.

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