CX1003 | MET/VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : CX1003

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CX1003 (CX-1003)

货号: PC-26906Not For Human Use, Lab Use Only.

CX1003 is a novel multitargeted receptor tyrosine kinase inhibitor targeting MET and VEGFR types 2 (VEGFR-2, KDR), also possesses inhibitory activities against several other kinases, such as Ret.

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生物&药学活性

CX1003 is a novel multitargeted receptor tyrosine kinase inhibitor targeting MET and VEGFR types 2 (VEGFR-2, KDR), also possesses inhibitory activities against several other kinases, such as Ret.
CX1003 has exhibited great potential for antitumor effects in various in vitro and animal studies.
CX1003 induced tumor regressions in xenograft mouse models derived from human gastric cell GTL16, human glioma cell U87MG and significantly decreased bone metastasis in ARCaPM prostate cancer models.

物理化学性质&存储条件

分子量	752.75
分子式	C38H43F2N4O8P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	diethyl ((4-(((4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidin-1-yl)methyl)phosphonate

参考文献

1. Li Y, et al. Bioanalysis. 2019 Aug;11(16):1483-1493.

2. Patent CN102093421B.

CX1003 (CX-1003)

生物&药学活性

物理化学性质&存储条件

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CX1003 (CX-1003)

生物&药学活性

物理化学性质&存储条件

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