CW069 | KIFC1 inhibitor | Probechem Biochemicals

Chemical Structure : CW069

CAS No.: 1594094-64-0

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CW069 (CW-069)

货号: PC-24692Not For Human Use, Lab Use Only.

CW069 (CW-069) is a specifc, allosteric small moelule inhibitor of microtubule motor protein HSET (encoded by KIFC1 in humans and Kifc5a in mice) with IC50 of 75 uM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

CW069 (CW-069) is a specifc, allosteric small moelule inhibitor of microtubule motor protein HSET (encoded by KIFC1 in humans and Kifc5a in mice) with IC50 of 75 uM.
CW069 shows statistically significant selectivity over KSP in vitro.
CW069 induces multipolar mitoses only in cells containing supernumerary centrosomes.
CW069 significantly reduced cell viability in the DTX-resistant cells
CW069 is a valuable tool for probing HSET function and, by reducing the growth of cells containing supernumerary centrosomes.

物理化学性质&存储条件

分子量	500.34
分子式	C23H21IN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid

参考文献

1. Watts CA, et al. Chem Biol. 2013 Nov 21;20(11):1399-410.

2. Sekino Y, et al. J Clin Med. 2019 Feb 9;8(2):225.

CW069 (CW-069)

生物&药学活性

物理化学性质&存储条件

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CW069 (CW-069)

生物&药学活性

物理化学性质&存储条件

参考文献

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