CVT-11127 (FMK13918, GS-456332)

Chemical Structure : CVT-11127

CAS No.: 1018674-83-3

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货号: PC-38545Not For Human Use, Lab Use Only.

CVT-11127 (FMK13918, GS-456332) is a specfiic small molecule stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 210 and 410 nM against rat microsomal SCD and HepG2 SCD, respectively.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CVT-11127 (FMK13918, GS-456332) is a specfiic small molecule stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 210 and 410 nM against rat microsomal SCD and HepG2 SCD, respectively.
CVT-11127 is selective for Δ9 desaturases, does not inhibit the activity of rat microsomal Δ5 and Δ6 desaturases at 30 uM.
CVT-11127 reduces cell proliferation in human lung and breast cancer cells, decreases de novo lipid synthesis from glucose.
CVT-11127 impairs the ligand-induced phosphorylation of epidermal growth factor (EGF) receptor, causing the inactivation of its downstream targets Akt, ERK and mammalian target of rapamycin in H460 lung cancer cells.

物理化学性质&存储条件

分子量	512.391
分子式	C25H23Cl2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(6-(3,4-dichlorobenzylamino)-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl) acetamide

参考文献

1. Koltun DO, et al. Bioorg Med Chem Lett. 2009;19:2048–52.

2. Natalia Scaglia, et al. PLoS One. 2009 Aug 27;4(8):e6812.