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首页-小分子抑制剂&激动剂-GPCR-Orexin Receptor-CVN766
CVN766

Chemical Structure : CVN766

CAS No.: 1803557-42-7

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CVN766 (CVN 766, CVN-766)

货号: PC-21740Not For Human Use, Lab Use Only.

CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.

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1 mg ￥1580 In stock
5 mg ￥3980 In stock
10 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: 97.8% (HPLC) Select Batch:

生物&药学活性

CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.
CVN766 displays slow off rate binding kinetics leading to an extended receptor occupancy in rats.
CVN766also demonstrates high brain permeability and a pharmacokinetic and safety profile suitable for clinical studies.

物理化学性质&存储条件

分子量 446.44
分子式 C20H21F3N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((1S,2S)-2-((3-ethyl-5-(trifluoromethyl)pyrazin-2-yl)amino)cyclopentyl)-3-(2H-1,2,3-triazol-2-yl)picolinamide

参考文献

1. Angela Glen, et al. Bioorg Med Chem Lett. 2024 Jan 29:129629.

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