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首页-小分子抑制剂&激动剂-Others-Other Targets-CVB4-57
CVB4-57

Chemical Structure : CVB4-57

CAS No.:

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CVB4-57

货号: PC-24611Not For Human Use, Lab Use Only.

CVB4-57 is a specific, reversible small molecule Connexin26 hemichannel (Cx26 hemichannel), reversibly inhibited the dye uptake at 5 uM without affecting the gap junction communication and barrier function.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CVB4-57 is a specific, reversible small molecule Connexin26 hemichannel (Cx26 hemichannel), reversibly inhibited the dye uptake at 5 uM without affecting the gap junction communication and barrier function.
CVB4-57 (1 uM) decreases the dye uptake in cells expressing hCx26 to 79 ± 17%.
CVB4-57 (20 uM) decreases the dye uptake in N2A cells expressing Cx46 to 72 ± 3%.
CVB4-57 could block Cx hemichannels with minimal impact on the epithelial physiology.
Cx26 hemichannels are more sensitive to both agents compared to Cx46.

物理化学性质&存储条件

分子量 405.34
分子式 C20H25BrN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-(4-(3-bromo-4-methoxybenzyl)piperazin-1-yl)ethyl)phenol

参考文献

1. Dierks A, et al. Pharmaceuticals (Basel). 2022 Sep 21;15(10):1173.

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