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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-CUDC-101
CUDC-101

Chemical Structure : CUDC-101

CAS No.: 1012054-59-9

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CUDC-101 (CUDC101, CUDC 101)

货号: PC-42467Not For Human Use, Lab Use Only.

CUDC-101 (CUDC101) is a potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CUDC-101 (CUDC101) is a potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
CUDC-101 exhibits efficient antiproliferative activity with greater potency (IC50<1 uM) than Vorinostat (SAHA), Erlotinib, Lapatinib.
CUDC-101 promotes tumor regression or inhibition in various cancer xenograft models including NSCLC, liver, breast, head and neck, colon, and pancreatic cancers.

物理化学性质&存储条件

分子量 434.4876
分子式 C24H26N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy-

参考文献

1. Cai X, et al. J Med Chem. 2010 Mar 11;53(5):2000-9.

2. Lai CJ, et al. Cancer Res. 2010 May 1;70(9):3647-56.

3. Wang J, et al. Mol Cancer Ther. 2013 Jun;12(6):925-36.

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