CT-996 | GLP-1R agonist | Probechem Biochemicals

Chemical Structure : CT-996

CAS No.: 2810808-95-6

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CT-996 (Tifeglipron, RO7795081, RG6652)

货号: PC-26360Not For Human Use, Lab Use Only.

Tifeglipron (CT-996, RO7795081, RG6652) is a potent, selective and orally active glucagon-like peptide 1 receptor (GLP-1R) agonist with EC50 of 0.49 nM.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Tifeglipron (CT-996, RO7795081, RG6652) is a potent, selective and orally active glucagon-like peptide 1 receptor (GLP-1R) agonist with EC50 of 0.49 nM.
CT-996 reduces the β-arrestin recruitment and GLP-1R internalization.
CT-996 suppresses postprandial blood glucose following a mixed meal tolerance test (MMTT) in mice expressing the human GLP-1 receptor and enhances glucose stimulated insulin secretion (GSIS) during an intravenous glucose challenge in obese monkeys.

物理化学性质&存储条件

分子量	579.60
分子式	C30H31F2N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((2S,4S)-4-((2-((2,4-difluorophenoxy)methyl)pyrimidin-4-yl)oxy)-2-methylpiperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid

参考文献

1. Drucker DJ. GLP-1-based therapies for diabetes, obesity and beyond. Nat Rev Drug Discov. 2025 Aug;24(8):631-650.

2. JIAN LUO, et al. Diabetes 14 June 2024; 73 (Supplement_1): 771–P.

CT-996 (Tifeglipron, RO7795081, RG6652)

生物&药学活性

物理化学性质&存储条件

参考文献

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CT-996 (Tifeglipron, RO7795081, RG6652)

生物&药学活性

物理化学性质&存储条件

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