CSH-4044 (CSH4044)

Chemical Structure : CSH-4044

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货号: PC-25793Not For Human Use, Lab Use Only.

CSH-4044 is a potent, specific, dual PIM and DYRK families of kinases inhibitor with IC50 of 6.0 nM and 24.8 nM for PIM3 and DYRK2 respectively.

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生物&药学活性

CSH-4044 is a potent, specific, dual PIM and DYRK families of kinases inhibitor with IC50 of 6.0 nM and 24.8 nM for PIM3 and DYRK2 respectively.
CSH-4044 (10 uM) reduces Tau phosphorylation at three residues, Tau S212, S202/T205 and T231 in in MiaPaCa-2 cells.
CSH-4044 suppresses PIM3-driven BAD phosphorylation in pancreatic cancer cells and reduced DYRK1A-mediated Tau phosphorylation in neuronal cells.

物理化学性质&存储条件

分子量	347.34
分子式	C16H13NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2,5-dihydroxy-4-methoxyphenyl)(6-hydroxy-5-methoxybenzo[d]thiazol-2-yl)methanone

参考文献

1. Gyula Bencze, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.22.683941.

CSH-4044 (CSH4044)

生物&药学活性

物理化学性质&存储条件

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CSH-4044 (CSH4044)

生物&药学活性

物理化学性质&存储条件

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