CSF1R-IN-3 | CSF1R inhibitor | Probechem Biochemicals

Chemical Structure : CSF1R-IN-3

CAS No.: 2760584-90-3

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CSF1R-IN-3 (Compound 21)

货号: PC-24733Not For Human Use, Lab Use Only.

CSF1R-IN-3 is a potent, selective and orally bioavailable CSF-1R inhibitor with IC50 of 2.1 nM.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CSF1R-IN-3 is a potent, selective and orally bioavailable CSF-1R inhibitor with IC50 of 2.1 nM.
CSF1R-IN-3 concentration-dependently inhibited the phosphorylation of CSF-1R and AKT in both BMDMs and PMA-differentiated THP-1 cells.
CSF1R-IN-3 shows high binding affinity to CSF-1R with a dissociation constant (KD) of 3.4 nM in SPR assays.
CSF1R-IN-3 (30 and 100 nM) potently inhibits the migration of macrophages.
CSF1R-IN-3 (30 and 100 nM) could downregulate the messenger RNA (mRNA) expressions of Il10, Arg1, Chil3, Retnla, and Vegf and upregulate the expressions of Il12, Tnf, Il6, and Nos2.
CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity.

物理化学性质&存储条件

分子量	574.69
分子式	C30H38N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazineacetamide, N-[5-[(Z)-[6-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-4-methyl-

参考文献

1. Qi Lv, et al. J Med Chem. 2021 Dec 9;64(23):17184-17208.

CSF1R-IN-3 (Compound 21)

生物&药学活性

物理化学性质&存储条件

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CSF1R-IN-3 (Compound 21)

生物&药学活性

物理化学性质&存储条件

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