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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEKK (MAP3K)-CS17919
CS17919

Chemical Structure : CS17919

CAS No.: 2379346-41-3

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CS17919 (CS-17919)

货号: PC-26152Not For Human Use, Lab Use Only.

CS17919 is a potent, selective Apoptosis signal‐regulating kinase 1 (ASK1) inhibitor with IC50 of 22.52 nM, shows cell protective, anti‐inflammatory, and antifibrotic effects in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CS17919 is a potent, selective Apoptosis signal‐regulating kinase 1 (ASK1) inhibitor with IC50 of 22.52 nM, shows cell protective, anti‐inflammatory, and antifibrotic effects in vitro and in vivo.

物理化学性质&存储条件

分子量 476.44
分子式 C22H20F4N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 5-[(cyclopropylcarbonyl)amino]-2-fluoro-4-methyl-N-[6-[4-[(1R)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

参考文献

1. Guoqiang Liao, et al. Animal Model Exp Med. 2025 Jan;8(1):102-113.

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