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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-LIM Kinase (LIMK)-CRT0105950
CRT0105950

Chemical Structure : CRT0105950

CAS No.: 1661845-86-8

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CRT0105950 (CRT-0105950, CRT 0105950)

货号: PC-70101Not For Human Use, Lab Use Only.

CRT0105950 (CRT 0105950) is a novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CRT0105950 (CRT 0105950) is a novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively.
CRT0105950 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
CRT0105950 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM).

物理化学性质&存储条件

分子量 393.889
分子式 C21H16ClN3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((5-(3-(2-chloro-4-methylphenyl)pyridin-4-yl)thiazol-2-yl)amino)phenol

参考文献

1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.

2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.

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