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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-LIM Kinase (LIMK)-CRT0105446
CRT0105446

Chemical Structure : CRT0105446

CAS No.: 1661846-05-4

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CRT0105446 (CRT-0105446, CRT 0105446)

货号: PC-70100Not For Human Use, Lab Use Only.

CRT0105446 (CRT-0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CRT0105446 (CRT-0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.
    CRT0105446 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
    CRT0105446 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM);

    物理化学性质&存储条件

    分子量 421.438
    分子式 C20H18F3N3O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(3-(4-methoxy-2-(trifluoromethyl)phenyl)pyridin-4-yl)thiazol-2-yl)isobutyramide

    参考文献

    1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.

    2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.

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