CRD-1441551 | MALT1 inhibitor | Probechem Biochemicals

Chemical Structure : CRD-1441551

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CRD-1441551 (CRD1441551)

货号: PC-27519Not For Human Use, Lab Use Only.

CRD-1441551 is a potent and highly selective, and reversible MALT1 inhibitor with IC50 of 33.5 nM.

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100 mg		Get quote

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生物&药学活性

CRD-1441551 is a potent and highly selective, and reversible MALT1 inhibitor with IC50 of 33.5 nM.
CRD-1441551 shows 100-fold selectivity over 57 tested proteases tested at 3 uM.
CRD-1441551 decreased amounts of cBCL10 in LM-Y1, LM-Y2, and S1T cells, with IC50 values of 6.9, 10, and 18 nmol/L, respectively.
CRD-1441551 increased RelB expression in LM-Y2 and S1T cells.
CRD-1441551 inhibited the growth of ATL cell lines with GI50 of 20.4, 0.8, and 15.7 μmol/L in LM-Y1, LM-Y2, and S1T cells, respectively.
CRD-1441551 induced apoptosis in LM-Y2 cells, induced cleaved caspase-3 and -7.
CRD-1441551 (60 or 100 mg/kg) induced an increase in RelB protein expression and downregulated IRF4 protein expression in S1T xenograft model tumor tissue.
CRD-1441551 exhibited variable antitumor effects across ATL models both in vitro and in vivo.

物理化学性质&存储条件

分子量	426.81
分子式	C17H17ClF2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-chloro-6-(difluoromethoxy)pyridin-3-yl)-3-(8-(1-methoxyethyl)-2-methylimidazo[1,2-b]pyridazin-7-yl)urea

参考文献

1. Kamiunten A, et al. iScience. 2026 Jul 23;29(8):116850.

CRD-1441551 (CRD1441551)

生物&药学活性

物理化学性质&存储条件

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CRD-1441551 (CRD1441551)

生物&药学活性

物理化学性质&存储条件

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