CRB-2131 | Nox inhibitor | Probechem Biochemicals

Chemical Structure : CRB-2131

加入收藏

CRB-2131 (CRB2131)

货号: PC-25383Not For Human Use, Lab Use Only.

CRB-2131 is a potent small molecule inhibitor of NADPH oxidase (Nox) isozymes with IC50 values of 200-300 nM for human Nox1, Nox2, Nox4, Nox5, Duox1, and Duox2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CRB-2131 is a potent small molecule inhibitor of NADPH oxidase (Nox) isozymes with IC50 values of 200-300 nM for human Nox1, Nox2, Nox4, Nox5, Duox1, and Duox2.
CRB-2131 potently inhibits the Aβ-induced i) production of ROS by HT-22 mouse hippocampal neuronal cells (IC50 = 5.98 nM) and phosphorylation of Tau in the HT-22 neuronal cells, ROS production by BV2 microglial cells (IC50 = 17.1 nM), expression of TNF-α and IL-1β by BV2 microglial cells and BV2 microglial-cell migration (IC50 = 0.96 nM).
CRB-2131 inhibits ROS generation and Tau phosphorylation in 5XFAD mice, suppresses Tau phosphorylation and neuronal inflammation.
CRB-2131 (1-10 mpk) improves behavioral-test outcomes in 5XFAD mice, protects 5XFAD mice from mature neuron death and enhances the regeneration of immature neurons.

物理化学性质&存储条件

分子量	351.26
分子式	C16H9F4N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-fluoro-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide

参考文献

1. Lee J, et al. Adv Sci (Weinh). 2025 Aug 18:e05495.

CRB-2131 (CRB2131)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CRB-2131 (CRB2131)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.