CQ3196 | RIOK2 inhibitor | Probechem Biochemicals

Chemical Structure : CQ3196

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CQ3196 (CQ-3196)

货号: PC-25339Not For Human Use, Lab Use Only.

CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays.

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生物&药学活性

CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays.
CQ3196 displays potent inhibitory effects on the proliferation of gastric cancer cells, with IC50 values of 0.46 μM in HGC-27 and 0.73 μM in AGS, as well as chronic myelogenous leukemia cells (IC50 = 0.90 μM in K562).
CQ3196 induces cell apoptosis at indicated concentrations in HGC-27 and AGS cells, modulates ribosome function and protein synthesis.
CQ3196 significantly decreases the phosphorylation of AKT in HGC-27 cells from 300 nM.
CQ3196 (25 mg/kg or 50 mg/kg), oral) inhibits tumor growth in the HGC-27 Tumor xenografted model.

物理化学性质&存储条件

分子量	577.61
分子式	C30H30F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(4-Methoxy-8-(6-methoxypyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-2-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-4-amine

参考文献

1. Haowen Ma, et al. J Med Chem. 2025 Aug 14. doi: 10.1021/acs.jmedchem.5c01424.

CQ3196 (CQ-3196)

生物&药学活性

物理化学性质&存储条件

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CQ3196 (CQ-3196)

生物&药学活性

物理化学性质&存储条件

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