CPUY192002 | Keap1-Nrf2 inhibitor | Probechem Biochemicals

Chemical Structure : CPUY192002

CAS No.: 1567836-15-0

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CPUY192002 (CPUY-192002)

货号: PC-28128Not For Human Use, Lab Use Only.

CPUY192002 is a potent protein-protein interaction (PPI) inhibitor of Keap1-Nrf2 with KD of 3.59 nM, effectively disrupts the Nrf2-Keap1 interaction with an EC50 of 28.6 nM in FP assays, also activates the Nrf2 transcription activity in the cell-based ARE-luciferase reporter assay.

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10 mg	￥2480	In stock
25 mg	￥3980	In stock
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生物&药学活性

CPUY192002 is a potent protein-protein interaction (PPI) inhibitor of Keap1-Nrf2 with KD of 3.59 nM, effectively disrupts the Nrf2-Keap1 interaction with an EC50 of 28.6 nM in FP assays, also activates the Nrf2 transcription activity in the cell-based ARE-luciferase reporter assay.

物理化学性质&存储条件

分子量	614.64
分子式	C28H26N2O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-(Naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

参考文献

1. Zheng-Yu Jiang, et al. J Med Chem. 2014 Mar 27;57(6):2736-45.

CPUY192002 (CPUY-192002)

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物理化学性质&存储条件

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CPUY192002 (CPUY-192002)

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