CPL302-253 |CAS:2019223-60-8 Probechem Biochemicals

Chemical Structure : CPL302-253

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CPL302-253 (CPL 302-253)

货号: PC-38318Not For Human Use, Lab Use Only.

CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM).

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生物&药学活性

CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM).
CPL302-253 displays no off-target interaction in KinomeScan assays.
CLP302-253 blocks activation of primary lymphoid cells in vitro, blocks IL-33 cytokine production in epithelial and T cell co-cultures.
CLP302-253 bocks eosinophil infiltration to the lungs and IL-33 expression in HDM induced asthma mouse model.

物理化学性质&存储条件

分子量	474.613
分子式	C26H34N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((4-(tert-butyl)piperazin-1-yl)methyl)-5-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

参考文献

1. Paweł Gunerka, et al. PLoS One. 2020 Jul 23;15(7):e0236159.

CPL302-253 (CPL 302-253)

生物&药学活性

物理化学性质&存储条件

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CPL302-253 (CPL 302-253)

生物&药学活性

物理化学性质&存储条件

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