CP612 | PKCε inhibitor | Probechem Biochemicals

Chemical Structure : CP612

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CP612 (CIDD-0150612)

货号: PC-24452Not For Human Use, Lab Use Only.

CP612 (CIDD-0150612) is a potent, specific inhibitor of protein kinase C epsilon (PKC epsilon, PKCε) with IC50 of 1.1 nM, 40-fold more selective against PKCε over ROCK1.

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生物&药学活性

CP612 (CIDD-0150612) is a potent, specific inhibitor of protein kinase C epsilon (PKC epsilon, PKCε) with IC50 of 1.1 nM, 40-fold more selective against PKCε over ROCK1.
CP612 did not inhibit atypical PKCζ, weakly inhibited conventional PKCβII and PKCγ, and within the nPKC subfamily, and a clean selectivity against 468 kinases using the scanMax assay panel from Eurofins-DiscoverX (468 kinases).
CP612 inhibits PKCε by competing with ATP.
CP612 could enter the brain and is cleared from brain at a much slower rate than from plasma.
CP612 inhibits PKCε-dependent mechanical hyperalgesia, does not alter morphine self-administration.
CP612 prevents and reverses hyperalgesia induced by morphine withdrawal.
CP612 shows beneficial effects on insulin action in hepatocytes and on fat mass and glucose homeostasis in mice.

物理化学性质&存储条件

分子量	462.98
分子式	C26H27ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(1-amino-2-(1-(4-chlorophenyl)cyclopentane-1-carboxamido)ethyl)-N-(pyridin-4-yl)benzamide

参考文献

1. Gregory-Flores A, et al. bioRxiv : the preprint server for biology, 2023 (2023), Article 543325

2. Agoncillo ML, et al. Eur J Pharmacol. 2025 Mar 5:177465.

CP612 (CIDD-0150612)

生物&药学活性

物理化学性质&存储条件

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CP612 (CIDD-0150612)

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物理化学性质&存储条件

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