CP-506 | DNA alkylating agent, Hypoxia-activated prodrug

Chemical Structure : CP-506

CAS No.: 2227303-52-6

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CP-506 (CP506)

货号: PC-25507Not For Human Use, Lab Use Only.

CP-506 is a DNA alkylating hypoxia-activated prodrug (HAP), shows selective antitumor effects for hypoxic tumor cells and causally related to tumor oxygenation.

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生物&药学活性

CP-506 is a DNA alkylating hypoxia-activated prodrug (HAP), shows selective antitumor effects for hypoxic tumor cells and causally related to tumor oxygenation.
CP-506 is designed to be resistant to AKR1C3 metabolism, ensuring highly specific hypoxia-dependent activation.
CP-506 demonstrates cytotoxicity selectively in hypoxic 2D and 3D cell cultures with normoxic/anoxic IC50 ratios up to 203.
CP-506 effectively decreased the hypoxic fraction and inhibited growth of a wide range of hypoxic xenografts.

物理化学性质&存储条件

分子量	585.49
分子式	C19H29BrN4O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(2-bromoethyl)-5-[(4-ethyl-1-piperazinyl)carbonyl]-2-(methylsulfonyl)-4-nitroanilino]ethyl methanesulfonate

参考文献

1. van der Wiel AMA, et al. Mol Cancer Ther. 2021 Dec;20(12):2372-2383.

CP-506 (CP506)

生物&药学活性

物理化学性质&存储条件

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