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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P-glycoprotein (P-gp)-CP-100356 hydrochloride
CP-100356 hydrochloride

Chemical Structure : CP-100356 hydrochloride

CAS No.: 142715-48-8

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CP-100356 hydrochloride (CP100356)

货号: PC-72608Not For Human Use, Lab Use Only.

CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
CP100356 did not block receptor binding at the cell surface, it inhibited low-pH-dependent membrane fusion mediated by arenavirus glycoproteins.
CP-100356 is an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat.
CP-100356 inhibited acetoxymethyl calcein (calcein-AM) uptake (IC50= 0.5 uM) and digoxin transport (IC50=1.2 uM) in human MDR1-transfected MDCKII cells.

物理化学性质&存储条件

分子量 597.109
分子式 C31H37ClN4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine hydrochloride

参考文献

1. Takenaga T, et al. Viruses. 2021 Sep 3;13(9):1763.

2. Kalgutkar AS, et al. J Pharm Sci. 2009 Dec;98(12):4914-27.

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