CNiBuC | SARS-CoV-2 RdRp inhibitor | Probechem Biochemicals

Chemical Structure : CNiBuC

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CNiBuC (5′-isobutyril prodrug of 1′-cyanocytidine)

货号: PC-25844Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

CNiBuC is the 5′-isobutyril ester prodrug of 1'-cyanocytidine and a reversible, competitive inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), shows anti-SARS-CoV-2 activity with EC50 of 3.6 uM in Vero cells.
CNiBuC had micro-to-nanomolar anti–SARS-CoV-2 activity in Vero, Calu-3, and Caco-2 cell lines.
CNiBuC (50 and 100 mg/kg, i.p., twice daily)reduces infectious virus titers against DELTA SARS-CoV-2 variant in Syrian hamsters.

物理化学性质&存储条件

分子量	338.32
分子式	C14H18N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate

参考文献

1. Amblard F, et al. Sci Adv. 2025 Oct 3;11(40):eadz5913.

CNiBuC (5′-isobutyril prodrug of 1′-cyanocytidine)

生物&药学活性

物理化学性质&存储条件

参考文献

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CNiBuC (5′-isobutyril prodrug of 1′-cyanocytidine)

生物&药学活性

物理化学性质&存储条件

参考文献

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