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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAPKAPK2 (MK2)-CMPD1
CMPD1

Chemical Structure : CMPD1

CAS No.: 41179-33-3

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CMPD1 (CMPD 1, MK2 inhibitor CMPD1)

货号: PC-70148Not For Human Use, Lab Use Only.

CMPD1 is a potent, selective, non-ATP-competitive inhibitor of p38α-mediated MAPK-activated protein kinase 2 (MK2, MAPKAPK2) phosphorylation with apparent Ki of 330 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CMPD1 is a potent, selective, non-ATP-competitive inhibitor of p38α-mediated MAPK-activated protein kinase 2 (MK2, MAPKAPK2) phosphorylation with apparent Ki of 330 nM.
CMPD1 dose not prevents p38α-mediated phosphorylation of MBP and ATF-2.
CMPD1 induces a significant G2/M arrest, also inhibits tubulin polymerization in glioblastoma cells.

物理化学性质&存储条件

分子量 349.4
分子式 C22H20FNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2'-fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide

参考文献

1. Davidson W, et al. Biochemistry. 2004 Sep 21;43(37):11658-71.

2. Gurgis F, et al. Cell Death Discov. 2015 Sep 7;1:15028.

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