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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldehyde Dehydrogenase (ALDH)-CLM296
CLM296

Chemical Structure : CLM296

CAS No.: 3067837-25-3

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CLM296 (CLM-296)

货号: PC-26285Not For Human Use, Lab Use Only.

CLM296 (CLM-296) is a highly potent, selective inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with IC50 of 2 nM for inhibition of ALDH1A3 in TNBC cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CLM296 (CLM-296) is a highly potent, selective inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with IC50 of 2 nM for inhibition of ALDH1A3 in TNBC cells.
CLM296 inhibits ALDH1A3-mediated Aldefluor fluorescence and is specific for ALDH1A3.
CLM296 (100 nM) specifically blocks ALDH1A3-mediated gene expression changes in TNBC cells.
CLM296 (0.4 and 4 mg/kg, i.p.) in specifically impedes ALDH1A3-mediated tumor growth and metastasis in MDA-MB-231 ALDH1A3 OE tumor-bearing mice.

物理化学性质&存储条件

分子量 430.51
分子式 C29H22N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1'-((2-phenylimidazo[1,2-a]pyridine-6,8-diyl)bis(4,1-phenylene))bis(ethan-1-one)

参考文献

1. MacLean MR, et al. iScience. 2026 Jan 31;29(3):114863.

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