CLEC-2 inhibitor MAS9

Chemical Structure : CLEC-2 inhibitor MAS9

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货号: PC-24478Not For Human Use, Lab Use Only.

MAS9 is a specific small molecule inhibitor targeting the C-type lectin-like receptor-2 (CLEC-2)-podoplanin interaction with IC50 of 4.5 uM, inhibits CLEC-2-mediated platelet aggregation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MAS9 is a specific small molecule inhibitor targeting the C-type lectin-like receptor-2 (CLEC-2)-podoplanin interaction with IC50 of 4.5 uM, inhibits CLEC-2-mediated platelet aggregation.
MAS9 (20-30 uM) significantly inhibits platelet aggregation to both CLEC-2 agonists rhodocytin and hemin.
MAS9 displaysinhibition for CLEC-2-mediated aggregation over other platelet receptors, GPVI, thromboxane prostanoid (TP) receptor, and proteinase activated receptors (PAR1 and PAR4).
MAS9 also displays selective inhibition of CLEC-2-mediated tyrosine kinase signalling. CLEC-2 and GPVI share similar proximal signalling events, including the phosphorylation and activation of the kinase Syk.
MAS9 has no inhibitory effect either on 0.3 μg·ml−1 CRP-XL or 0.1 U·ml−1 thrombin-mediated platelet aggregation, also shows no inhibitory effect on lower concentrations of thrombin or U46619-mediated aggregation.
MAS9 inhibits CLEC-2-dependent platelet adhesion but inhibits platelet spreading to all substrates.
MAS9 (10-30 uM) inhibits platelet adhesion to human dermal lymphatic endothelial cells.

物理化学性质&存储条件

分子量	314.39
分子式	C18H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 1-[(8-hydroxy-5-quinolinyl)methyl]-3-piperidinecarboxylate

参考文献

1. Sowa MA, et al. Br J Pharmacol. 2025 Apr 23. doi: 10.1111/bph.70036.