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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-CL27c
CL27c

Chemical Structure : CL27c

CAS No.: 1380227-11-1

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CL27c

货号: PC-35887Not For Human Use, Lab Use Only.

CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor.
    CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e.
    CL27c readily reduces Akt/PKB phosphorylation in chronic lymphocytic leukemia (CLL) cells stimulated with anti-IgM antibodies, as well as in murine neutrophils and bone marrow-derived macrophages (BMDM) stimulated with C5a.
    CL27c reduces insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action.
    CL27c reduces inflammation and improves lung function in murine models of acute or glucocorticoid-resistant neutrophilic asthma.

    物理化学性质&存储条件

    分子量 445.479
    分子式 C24H23N5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl 3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoate

    参考文献

    1. Campa CC, et al. Nat Commun. 2018 Dec 12;9(1):5232.

    2. Pirali T, et al. ChemMedChem. 2017 Sep 21;12(18):1542-1554.

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