CK2 bivalent inhibitor Biv5

Chemical Structure : CK2 bivalent inhibitor Biv5

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货号: PC-24756Not For Human Use, Lab Use Only.

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50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CK2 bivalent inhibitor Biv5 is a picomolar bivalent inhibitor of protein casein kinase 2 (CK2) with IC50 of 51 pM (CK2α), shows potent antiviral activity against SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells.
Biv5 demonstrated high potency, reducing intracellular viral RNA production by approximately three logs at 20 μM.
Biv5 inhibited SARS-CoV-2 infection in HEK-ACE2-TMPRSS2 cells, as evidenced by decreased nucleoprotein detection.
Biv5 dose-dependently reduced OC43 RNA production in HRT18 cells.
Biv5 exhibited excellent selectivity against 18 known CX-4945 targets.

物理化学性质&存储条件

分子量	567.13
分子式	C34H35ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((8-(((2-chloro-[1,1′-biphenyl]-4-yl)methyl)amino)octyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid

参考文献

1. Grenier D, et al. Eur J Med Chem. 2025 May 29;296:117826.