CK147 | Sec61 inhibitor | Probechem Biochemicals

Chemical Structure : CK147

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CK147 (CK-147, CK 147)

货号: PC-20794Not For Human Use, Lab Use Only.

CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.

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生物&药学活性

CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.
CK147 binds to a site near the plug domain and induces a partially opened conformation of Sec61.
CK147 markedly inhibits the cotranslational translocation of huCD4 in a cell-free in vitro translation assay with IC50 of 0.36 uM (HEK293T cells), with little impact on the ER import of preprolactin.

物理化学性质&存储条件

分子量	616.88
分子式	C32H48N4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((9-(cyclohexylmethyl)-3-methylene-5-tosyl-1,5,9-triazacyclododecan-1-yl)sulfonyl)-N,N-dimethylaniline

参考文献

1. Chawla R, et al. J Med Chem. 2016 Mar 24;59(6):2633-47.

2. Eva Pauwels, et al. Sci Adv. 2023 Mar 3;9(9):eadf0797.

CK147 (CK-147, CK 147)

生物&药学活性

物理化学性质&存储条件

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CK147 (CK-147, CK 147)

生物&药学活性

物理化学性质&存储条件

参考文献

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