CK-4021586 (Ulacamten, CK-586) | Cardiac myosin inhibitor

Chemical Structure : CK-586

CAS No.: 2830607-59-3

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CK-586 (Ulacamten, CK-4021586, CK586)

货号: PC-22762Not For Human Use, Lab Use Only.

CK-4021586 (Ulacamten, CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

CK-4021586 (Ulacamten, CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.
CK-586 is a partial inhibitor of cardiac myofibrillar ATPase activity (EC50=2.9 µM) that requires the regulatory light chain.
In preclinical models, CK-586 reduced cardiac hypercontractility by decreasing the number of active myosin cross-bridges during cardiac contraction thereby reducing the contractile force, without effect on calcium transients.

物理化学性质&存储条件

分子量	405.45
分子式	C21H25F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,5,8-Triazaspiro[3.5]nonane-2-carboxaldehyde, 5-[(3,4-difluorophenyl)methyl]-8-(trans-4-methylcyclohexyl)-6,9-dioxo-

参考文献

1. Victor N Rivas, et al. Sci Rep. 2024 May 27;14(1):12038.

2. Saswata Sankar Sarkar, et al. Biophys J, VOLUME 122, ISSUE 3, SUPPLEMENT 1, 122A, FEBRUARY 10, 2023

CK-586 (Ulacamten, CK-4021586, CK586)

生物&药学活性

物理化学性质&存储条件

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CK-586 (Ulacamten, CK-4021586, CK586)

生物&药学活性

物理化学性质&存储条件

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