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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-CIM-834
CIM-834

Chemical Structure : CIM-834

CAS No.:

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CIM-834 (CIM834)

货号: PC-24313Not For Human Use, Lab Use Only.

CIM-834 is a potent, first-in-class, orally efficacious small molecule coronavirus assembly inhibitor, blocks the assembly of SARS-CoV-2, targets the viral membrane (M) protein, inhibits replication of a panel of SARS-CoV-2 isolates with mean EC50 of 112 nM and 84 nM in VeroE6–GFP and A549ACE2+TMPRSS2 cells, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CIM-834 is a potent, first-in-class, orally efficacious small molecule coronavirus assembly inhibitor, blocks the assembly of SARS-CoV-2, targets the viral membrane (M) protein, inhibits replication of a panel of SARS-CoV-2 isolates with mean EC50 of 112 nM and 84 nM in VeroE6–GFP and A549ACE2+TMPRSS2 cells, respectively.
CIM-834 also inhibits the replication of SARS-CoV (EC50 of 640 nM in VeroE6–GFP cells and 530 nM in VeroE6 cells) and has low micromolar activity against HCoV-OC43, but it lacks activity against MERS-CoV and selected alphacoronaviruses (HCoV-229E, HCoV-NL63, feline infectious peritonitis virus (FIPV) and PEDV).
CIM-834 reduces virus yield of SARS-CoV-2 B.1.1.7 four days after infection in primary human nasal epithelial cells cultured at the air–liquid interface by 4.1 and more than 5log10, at CIM-834 concentrations of 1 and 3  uM, respectively.
CIM-834 reduced lung viral titres to nearly undetectable levels in SARS-CoV-2 infected SCID mice and hamsters.

物理化学性质&存储条件

分子量 494.69
分子式 C27H42N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((1-(5-isobutyl-4,6-dimethylpyrimidin-2-yl)piperidin-4-yl)(methyl)amino)-N-(2-(pyrrolidin-1-yl)ethyl)pyridazine-4-carboxamide

参考文献

1. Laporte M, et al. Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08773-x.

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